PARTICIPANT RANDOMIZATION IN COMPLEX TRIAL DESIGNS
نویسندگان
چکیده
منابع مشابه
Minimal sufficient balance randomization for sequential randomized controlled trial designs: results from the ESCAPE trial
BACKGROUND We describe the implementation of minimal sufficient balance randomization, a covariate-adaptive randomization technique, used for the "Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times" (ESCAPE) trial. METHODS The ESCAPE trial is a prospective, multicenter, randomized clinical trial that enrolle...
متن کاملBias due to participant overlap in two‐sample Mendelian randomization
Mendelian randomization analyses are often performed using summarized data. The causal estimate from a one-sample analysis (in which data are taken from a single data source) with weak instrumental variables is biased in the direction of the observational association between the risk factor and outcome, whereas the estimate from a two-sample analysis (in which data on the risk factor and outcom...
متن کاملRandomization tests for restricted alternating treatments designs.
Alternating Treatments Designs (ATD) with random assignment of the treatments to the measurement times provide very powerful single-case experiments. However, complete randomization might cause too many consecutive administrations of the same treatment to occur in the design. In order to exclude these possibilities, an ATD with restricted randomization can be used. In this article we provide a ...
متن کاملPhase II Multi-Arm Clinical Trial Designs and Randomization with Covariates via Empirical Weighting
In phase II clinical trials, multiple competing treatments are under the study. Vast literature exists on how to allocate the incoming patients to one of the treatments rationally, leading to various optimal trial designs with different optimality criteria under different design scenarios. In some situations, the covariates of incoming patients are known, this information can be incorporated in...
متن کاملSurveying clinical trial participant satisfaction
Methods Using a modified version of the SERVQUAL questionnaire, participants were asked to assign a score to each of 10 service quality factors (SQFs) on a 5 point Likert scale to indicate (i) how important they considered each SQF in relation to their attendance at the clinic & (ii) their actual experience that day. Participants were also invited to describe anything they found particularly sa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2017
ISSN: 2399-5300
DOI: 10.1093/geroni/igx004.2334